Pain Articles

Introduction Tapentadol and tramadol occupy the same therapeutic niche: moderate to severe pain that hasn’t responded adequately to non-opioid analgesics. Both are centrally acting opioid analgesics, and both pair mu-opioid receptor activity with a second, non-opioid mechanism. The similarities largely end there. The two differ meaningfully in potency, onset, metabolic pathway, interaction profile, tolerability, and […]

Introduction Tapentadol and Oxycodone are two important opioid analgesic medications used for moderate to severe pain management that, despite the similarity in use, vastly differ in mechanism of action, safety, and effectiveness. Tapentadol is a safer option than Oxycodone with similar effectiveness. Literature has demonstrated improved gastronomical tolerability in Tapentadol users, coupled with a lower